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ObjectiveTo observe the effect of Dahuang Xiezhuo prescription on the clinical symptoms， blood uric acid， and renal tubular function of patients with immunoglobulin A （IgA） nephropathy in stages 1-2 of chronic kidney disease （CKD） complicated with hyperuricemia （HUA）. MethodSixty patients with IgA nephropathy in stages 1-2 of CKD complicated with HUA of spleen and kidney deficiency and combined turbidity and blood stasis syndromes were randomly divided into an observation group and a control group， with 30 cases in each group. The patients in the control group received basic treatment， i.e.， losartan potassium tablets 50-100 mg/time， once per day， and sodium bicarbonate tablets 0.5 g/time， three times per day by oral administration， combined with low-salt， low-fat， and low-purine diet. The patients in the observation group received Dahuang Xiezhuo prescription on the basis of basic treatment， one dose per day， twice a day in the morning and evening with warm water. Both groups were treated for two months. The total scores of traditional Chinese medicine（TCM）syndrome， blood pressure， 24 h urinary protein （24 h UTP）， blood urea nitrogen （BUN）， serum creatinine （SCr） ［glomerular filtration rate （eGFR） was calculated by CKD-epidemiology collaboration （CKD-EPI） formula］， serum uric acid （SUA）， and renal tubular function indexes ［urinary α1-microglobulin （α1-MG）， urinary β2-microglobulin （β2-MG）， urinary kidney injury molecule-1 （KIM-1）， and neutrophil gelatinase-associated lipocalin （NGAL）］ of the two groups before treatment and two months after treatment were recorded. The clinical efficacy of the two groups was evaluated two months after treatment. ResultAfter 2 months of treatment，the total effective rate in the observation group was 81.48%（22/27），higher than 50.00%（14/28） in the control group（χ2 =6.661，P<0.05）. The total scores of TCM syndrome， 24 h UTP， and SUA in the observation group and the observation group were lower than those before treatment （P<0.05）， and compared with the control group after treatment， the observation group decreased more significantly （P<0.05）. After treatment， the blood pressure in the observation group and the observation group was lower than that before treatment （P<0.05）， and there was no significant difference in blood pressure between the two groups after treatment. After treatment， the levels of urinary α1-MG， β2-MG， KIM-1， and NGAL in the two groups were lower than those before treatment （P<0.05）， and the observation group was lower than the control group after treatment （P<0.05）. There were no significant inter-group and intra-group differences in BUN， SCr， and eGFR levels before and after treatment. There were no obvious abnormalities in blood routine， liver function， and electrolytes before and after treatment in the two groups， and no adverse reactions such as allergies occurred. ConclusionDahuang Xiezhuo prescription can effectively improve the clinical symptoms of IgA nephropathy with HUA （CKD1-2） patients with spleen and kidney deficiency and combined turbidity and blood stasis syndromes， reduce blood uric acid level， alleviate renal tubular injury， and protect the kidney. The curative effect is better than that of basic treatment.
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Objective To investigate the serum cystatin C (CysC) and urinary albumin excretion (mALB) joint detection in di‐agnosis of early diabetic nephropathy injury .Methods 120 cases of determination of CysC and microalbuminuria in type 2 diabetic patients and 40 healthy people and related clinical and biochemical parameters were measured ,and the various factors by correlation analysis ,the determination of differences in early renal damage in diabetes and healthy people .Results the early diabetic nephropa‐thy group ,diabetic nephropathy group serum cystatin C and urinary microalbumin is higher than the normal control group ,CysC and mALB level had significant difference ,the difference was statistically significant (P<0 .05) ,the mALB was positively correla‐ted with serum CysC levels (r=0 .662 ,P<0 .05) ,and no obvious correlation of serum Cr ,BUN levels and mALB .Conclusion trace albumin serum cystatin C and urine is reflecting early renal function injury sensitive and reliable index ,serum cystatin C com‐bined detection of urine micro albumin contributes to kidney disease early diagnosis ,treatment and prognosis judgement .
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Objective To investigate the value of serum α1 acid glycoprotein(AAG) and Homocysteine(Hcy) in different stage of renal damage in type 2 diabetes(T2DM ) .Methods a total of 128 patients with T2DM were recruited from January 2013 to Octo‐ber 2013 ,According to 24 h urinary albumin excretion rate (UAER) were divided into the first group ,the second and third groups , and choose 80 healthy cases over the same period as the normal control group .Serum AAG ,Hcy ,creatinine (Cr) and blood urea ni‐trogen (BUN) were detected ,the test results were analyzed statistically .Results There were significant differences in type 2 diabe‐tes mellitus group ,early diabetic nephropathy group ,clinical diabetic nephropathy group of the serum AAG ,Hcy levels(P<0 .05) , there were positively correlated (r=0 .673 ,P<0 .05) between UAER and serum AAG levels ,and were positively correlated (r=0 .35 ,P<0 .05) between UAER and Hcy levels .Conclusion Combined detection of serum AAG ,Hcy have a significant for early diagnosis of diabetic nephropathy and assessing the degree of renal injury in diabetes .
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Objective To introduce the operative mode of circumcision of the root skin of penis for the treatment of redundant prepuce and its efficacy. Methods The operative indications included redundant prepuce and imperfect phimosis.With the will of patients,circumcision of the root skin of penis was performed on 256 cases of redundant prepuce and imperfect phimosis (group A).One section of the root skin of penis was resected,and the wound was sewed up.The skin of penis was moved from far to nearby and the prepuce was shortened finally.Compared with group A,group B (another 265 cases with the same indications) were treated with the traditional circumcision of prepuce.The amount of bleeding during operation and postoperative complications (bleeding, hematoma, dropsy, pain, infection of wound) were compared between the 2 groups. Results Intraoperative hemorrhagic amount was (3?1)ml in group A and (10?2)ml in group B( t=-50.36,P